Preparation of Functionalized Dialkylzinc Reagents via an Iodine-Zinc Exchange Reaction. Highly Enantioselective Synthesis of Functionalized Secondary Alcohols

DOI: 10.1021/jo00033a008

Source and publish data:

Journal of Organic Chemistry p. 1956 - 1958 (1992)

Update date:2022-08-05

Topics: Enantioselective synthesis

Authors:

Rozema, Michael J.

AchyuthaRao, Sidduri

Knochel, Paul

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Article abstract of DOI:10.1021/jo00033a008

Functionalized dialkylzincs are obtained by the reaction of polyfunctional alkyl iodides with Et2Zn in excellent yield.Their treatment with aldehydes, in the presence of the titanium catalyst 6, affords functionalized secondary alcohols with high enantios

Full text of DOI:10.1021/jo00033a008

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