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Basic Information
CAS No.: 98319-26-7
Name: Finasteride
Molecular Structure:
Molecular Structure of 98319-26-7 (Finasteride)
Formula: C23H36N2O2
Molecular Weight: 372.551
Synonyms: Proscar (TN);Finasteride (USP);Finpecia;4-Azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-, (5alpha,17beta)-;Proscar;Finastid;Propecia (TN);Propecia;MK-0906;MK 906;Finasteride [USAN:BAN:INN];MK-906;Prostide;Chibro-Proscar;Finasterida [INN-Spanish];Finasteridum [INN-Latin];N-tert-butyl-4-aza-5alpha-androsta-3-oxo-17beta-carboxamide;Finasteride 99%;
EINECS: 620-534-3
Density: 1.065 g/cm3
Melting Point: 253 °C
Boiling Point: 576.6 °C at 760 mmHg
Flash Point: 177.4 °C
Solubility: DMSO: 32 mg/mL, soluble; insoluble in water
Appearance: white to off-white crystalline powder
Hazard Symbols: HarmfulXn,ToxicT,IrritantXi
Risk Codes: 22-61-60-36/37/38
Safety: 36/37/39-45-53-36-26
PSA: 58.20000
LogP: 4.53420
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    98319-26-7

    High Quality 99% Finasteride pure CAS:98319-26-7 EP/USP Standard

    Min.Order: 100 Gram

    FOB Price:  USD $ 0.0-0.0

    Appearance:White to off-white crystalline powder Storage:Room temperature Package:1kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in china

    Founded in 2005, Sartort, located in Hangzhou, is a leading company engaging in chemistry, pharmaceutical and advanced materials. At present, Sartort has such controlled subsidi

  •  Hangzhou Sartort Biopharma Co., Ltd

     China (Mainland)  |  Contact Details

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  • Casno:

    98319-26-7

    Hair Treatment Powder Quality Standard API Finasteride raw Powder Finasteride

    Min.Order: 100 Gram

    FOB Price:  USD $ 88.0-88.0

    We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

    Xi'an faithful BioTech Co., Ltd. is located in the beautiful city of xian. We are mainly engaged in the production of pharmaceutical intermediates, natural active ingredients, nat

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-13137770562

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  • Finasteride

  • Casno:

    98319-26-7

    Finasteride

    Min.Order: 10 Gram

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  • Finasteride

  • Casno:

    98319-26-7

    Finasteride

    Min.Order: 25 Kilogram

    FOB Price:  USD $ 0.0-0.0

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  • Factory Supply Finasteride With Best Quality

  • Casno:

    98319-26-7

    Factory Supply Finasteride With Best Quality

    Min.Order: 10 Gram

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    1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

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Specification

1. Introduction of Finasteride

Finasteride, with the IUPAC Name of (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-Butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide, is one kind of white crystalline powder. Its classification code are Drug / Therapeutic Agent; Enzyme inhibitors; Inhibitor [alpha reductase] and Reproductive Effect. This chemical belongs to the Product Categories which include Active Pharmaceutical Ingredients; API; Biochemistry; Steroids; Steroids (Others); Intermediates & Fine Chemicals; Pharmaceuticals; Vitamin Ingredients; Intracellular receptor.

2. Properties of Finasteride

Finasteride has the following datas: (1)Index of Refraction: 1.523; (2)Molar Refractivity: 106.9 cm3; (3)Molar Volume: 349.5 cm3; (4)Density: 1.065 g/cm3; (5)Flash Point: 177.4 °C; (6)Melting point: 253 °C; (7)Surface Tension: 37.7 dyne/cm; (8)Water solubility: insoluble; (9)Solubility: DMSO: 32 mg/mL, soluble; (10)Enthalpy of Vaporization: 86.34 kJ/mol; (11)Boiling Point: 576.6 °C at 760 mmHg; (12)Vapour Pressure: 2.69E-13 mmHg at 25 °C.

3. Structure Descriptors of Finasteride

You could convert the following datas into the molecular structure:
(1).Canonical SMILES: CC12CCC3C(C1CCC2C(=O)NC(C)(C)C)CCC4C3(C=CC(=O)N4)C
(2).Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC(C)(C)C)CC[C@@H]4[C@@]3(C=CC(=O)N4)C
(3).InChI: InChI=1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
(4).InChIKey: DBEPLOCGEIEOCV-WSBQPABSSA-N

4. Toxicity of Finasteride

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 1gm/kg (1000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.
mouse LD50 intraperitoneal 372mg/kg (372mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.
mouse LD50 oral 486mg/kg (486mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.
mouse LD50 subcutaneous > 2gm/kg (2000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.
rat LD50 intraperitoneal 885mg/kg (885mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
GASTROINTESTINAL: PERITONITIS
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.
rat LD50 oral 418mg/kg (418mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.

5. Safety Information of Finasteride

Hazard Codes: HarmfulXn,ToxicT,IrritantXi
Risk Statements: 22-61-60-36/37/38 
R22:Harmful if swallowed. 
R61:May cause harm to the unborn child. 
R60:May impair fertility. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 36/37/39-45-53-36-26 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S53:Avoid exposure - obtain special instructions before use. 
S36:Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: CL5245000

6. Use of Finasteride

Finasteride (CAS NO.98319-26-7) is used as a treatment in benign prostatic hyperplasia (BPH) in low doses, and prostate cancer in higher doses. A May, 2008 study indicates that finasteride reduces the rate of prostate cancer by 30%. It is also indicated for use in combination with doxazosin therapy to reduce the risk for symptomatic progression of BPH. Additionally, it is registered in many countries for androgenetic alopecia (male-pattern baldness).