CAS No.98319-26-7,Finasteride Suppliers

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Basic Information

Molecular Structure:
CAS No.:	98319-26-7
Name:	Finasteride
Article Data:	40
Cas Database

Formula:	C₂₃H₃₆N₂O₂
Molecular Weight:	372.551
Synonyms:	Proscar (TN);Finasteride (USP);Finpecia;4-Azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-, (5alpha,17beta)-;Proscar;Finastid;Propecia (TN);Propecia;MK-0906;MK 906;Finasteride [USAN:BAN:INN];MK-906;Prostide;Chibro-Proscar;Finasterida [INN-Spanish];Finasteridum [INN-Latin];N-tert-butyl-4-aza-5alpha-androsta-3-oxo-17beta-carboxamide;Finasteride 99%;
EINECS:	620-534-3
Density:	1.065 g/cm³
Melting Point:	253 °C
Boiling Point:	576.6 °C at 760 mmHg
Flash Point:	177.4 °C
Solubility:	DMSO: 32 mg/mL, soluble; insoluble in water
Appearance:	white to off-white crystalline powder
Hazard Symbols:	Xn,T,Xi
Risk Codes:	22-61-60-36/37/38
Safety:	36/37/39-45-53-36-26
PSA:	58.20000
LogP:	4.53420

Raw Materials

302-97-6

99-76-3

63-05-8

Total:313 Page 1 of 9 1 2 3 4 5 6 …9 Next>>

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Specification

1. Introduction of Finasteride

Finasteride, with the IUPAC Name of (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-Butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide, is one kind of white crystalline powder. Its classification code are Drug / Therapeutic Agent; Enzyme inhibitors; Inhibitor [alpha reductase] and Reproductive Effect. This chemical belongs to the Product Categories which include Active Pharmaceutical Ingredients; API; Biochemistry; Steroids; Steroids (Others); Intermediates & Fine Chemicals; Pharmaceuticals; Vitamin Ingredients; Intracellular receptor.

2. Properties of Finasteride

Finasteride has the following datas: (1)Index of Refraction: 1.523; (2)Molar Refractivity: 106.9 cm³; (3)Molar Volume: 349.5 cm³; (4)Density: 1.065 g/cm³; (5)Flash Point: 177.4 °C; (6)Melting point: 253 °C; (7)Surface Tension: 37.7 dyne/cm; (8)Water solubility: insoluble; (9)Solubility: DMSO: 32 mg/mL, soluble; (10)Enthalpy of Vaporization: 86.34 kJ/mol; (11)Boiling Point: 576.6 °C at 760 mmHg; (12)Vapour Pressure: 2.69E-13 mmHg at 25 °C.

3. Structure Descriptors of Finasteride

You could convert the following datas into the molecular structure:
(1).Canonical SMILES: CC12CCC3C(C1CCC2C(=O)NC(C)(C)C)CCC4C3(C=CC(=O)N4)C
(2).Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC(C)(C)C)CC[C@@H]4[C@@]3(C=CC(=O)N4)C
(3).InChI: InChI=1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
(4).InChIKey: DBEPLOCGEIEOCV-WSBQPABSSA-N

4. Toxicity of Finasteride

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 1gm/kg (1000mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.
mouse	LD50	intraperitoneal	372mg/kg (372mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.
mouse	LD50	oral	486mg/kg (486mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.
mouse	LD50	subcutaneous	> 2gm/kg (2000mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.
rat	LD50	intraperitoneal	885mg/kg (885mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: PERITONITIS	Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.
rat	LD50	oral	418mg/kg (418mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.
rat	LD50	subcutaneous	> 2gm/kg (2000mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994.

5. Safety Information of Finasteride

Hazard Codes: Harmful

Xn,

Xi
Risk Statements: 22-61-60-36/37/38
R22:Harmful if swallowed.
R61:May cause harm to the unborn child.
R60:May impair fertility.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 36/37/39-45-53-36-26
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53:Avoid exposure - obtain special instructions before use.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: CL5245000

6. Use of Finasteride

Finasteride (CAS NO.98319-26-7) is used as a treatment in benign prostatic hyperplasia (BPH) in low doses, and prostate cancer in higher doses. A May, 2008 study indicates that finasteride reduces the rate of prostate cancer by 30%. It is also indicated for use in combination with doxazosin therapy to reduce the risk for symptomatic progression of BPH. Additionally, it is registered in many countries for androgenetic alopecia (male-pattern baldness).