Man-designed bleomycins: Significance of the binding sites as enzyme models and of the stereochemistry of the linker moiety

Article abstract of DOI:10.1016/S0040-4020(01)90783-5

Comparison of the DNA cleavage activity of man-designed bleomycins demonstrates that belomycins are small enzymes comprised of a catalytic site and a binding site. The linker moiety is shown to be significant for DNA binding, and inversion of its stereoch