Imidazo[1,2-a]pyridines. II. Ozonolysis of imidazo[1,2-a]pyridines and synthesis of cardiotonic agents

DOI: 10.1248/cpb.40.666

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 666 - 674 (1992)

Update date:2022-09-26

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Authors:

Yamanaka

Suda Suda

Yoneda Yoneda

Ohhara Ohhara

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Article abstract of DOI:10.1248/cpb.40.666

The metabolite of loprinone (E-1020) in dogs, 5-(2-aminopyridin-5-yl)-1,2-dihydro-6-methyl-2-oxo-3-pyridine carbonitrile (9), was prepared via ozonolysis of imidazo[1,2-a]pyridinylpyridines and evaluated for positive inotropic activity. Its potency was le

Full text of DOI:10.1248/cpb.40.666

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