Synthetic Communications p. 119 - 126 (2015)
Update date:2022-08-04
Topics:
Kaki, Venkata Rao
Akkinepalli, Raghuram Rao
Deb, Pran Kishore
Pichika, Mallikarjuna Rao
A simple, efficient, and environmental friendly procedure was developed based on the Gewald reaction for the synthesis of 2-aminothiophenes using a basic ionic liquid [bmIm]OH as both catalyst and solvent. Besides being a green protocol, the method offers advantages of successful synthesis of a variety of alkyl, aryl, alkoxy, and alkylamino-2-aminothiophenes in good yields.
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