The synthesis of chiral decalones, (-)-1,1,4a-trimethyl-2-decalol and (+)-geosmin from S-(+)-carvone (part 3)

Article abstract of DOI:10.1016/S0040-4020(01)88303-4

The cholesterol biosynthesis inhibitor (-),1,1,4a-trimethyl-2-decalol (4), the chiral decalones 6 and 7, and (+)-geosmin (9 were synthesized from S-(+)-carvone. Annelation of S-(-)-dihydrocarvone followed by methylation gave compound 8 which was used as a