Organic and Biomolecular Chemistry p. 6342 - 6345 (2019)
Update date:2022-09-26
Topics:
Hu, Jiao
Zhou, Gang
Tian, Yawei
Zhao, Xiaoming
Using LiCl as a chlorine source, the chlorination of 2-aminopyridines or 2-aminodiazines in the presence of Selectfluor and DMF is established under mild conditions. This method gives chlorinated pyridines or diazines in good to high yields with high regioselectivities. Also, this method is extended to the bromination of 2-aminopyridines or 2-aminodiazines by using LiBr. The regioselectivity of the chlorination reaction is strongly dependent upon the substituent pattern in either the 2-aminopyridines or 2-aminodiazines. The synthesis of Buparlisib from chlorinated pyridines was explored. A study of the mechanism revealed that this chlorination occurs via either a pyridine or diazine radical process.
View MoreJinan YouCheng Pharmatech Co.,Ltd
Contact:+86-18653163205
Address:No.750, Shunhua Road, University Science Park, High-tech Zone, Jinan City
puyang hongda shengdao new material co.,ltd.
Contact:+86-393- 4896278
Address:No.29 East Zhongyuan Road
Contact:+86-22-26358246
Address:601-4-20, Fujiayuan, Tiantai Road, Hebei District, Tianjin, China
Qingdao S. H. Huanyu Imp. & Exp. Co., Ltd.
Contact:86-532-88250866
Address:Room 615, World Trade Centre Building B, Hongkong Middle Roda 6#, Qingdao, Shandong, China
Shanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.
Contact:+86-21-51320130-801, 816
Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai
Doi:10.1021/om400199u
(2013)Doi:10.1016/j.tetlet.2013.04.005
(2013)Doi:10.1016/j.bmcl.2019.126878
(2020)Doi:10.1021/acscatal.7b00986
(2017)Doi:10.1021/jo400572h
(2013)Doi:10.1016/0008-6215(91)84040-L
(1991)