2-Nitroimidazole Dual-Function Bioreductive Drugs: Studies on the Effects on Regioisomerism and Side-Chain Structural Modifications on Differential Cytotoxicity and Radiosensitization by Aziridinyl and Oxiranyl Derivatives

DOI: 10.1021/jm00097a015

Source and publish data:

Journal of Medicinal Chemistry p. 3573 - 3578 (1992)

Update date:2022-08-04

Topics:

Authors:

Naylor, Matthew A.

Threadgill, Michael D.

Webb, Paul

Stratford, Ian J.

Stephens, Miriam A.

et al. et al.

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Article abstract of DOI:10.1021/jm00097a015

A series of 2-nitroimidazoles bearing side chains terminating in or containing aziridinyl and oxiranyl groups has been prepared, and the compounds were evaluated in vitro as hypoxia-selective bioreductively-activated cytotoxins and selected compounds test

Full text of DOI:10.1021/jm00097a015

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