2-Nitroimidazole Dual-Function Bioreductive Drugs: Studies on the Effects on Regioisomerism and Side-Chain Structural Modifications on Differential Cytotoxicity and Radiosensitization by Aziridinyl and Oxiranyl Derivatives

DOI: 10.1021/jm00097a015

Source and publish data:

Journal of Medicinal Chemistry p. 3573 - 3578 (1992)

Update date:2022-08-04

Topics:

Authors:

Naylor, Matthew A.

Threadgill, Michael D.

Webb, Paul

Stratford, Ian J.

Stephens, Miriam A.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00097a015

A series of 2-nitroimidazoles bearing side chains terminating in or containing aziridinyl and oxiranyl groups has been prepared, and the compounds were evaluated in vitro as hypoxia-selective bioreductively-activated cytotoxins and selected compounds test

Full text of DOI:10.1021/jm00097a015

Products guided by the article

Product name:1,2-cis-2,3-trans-3-aziridin-1-yl-2-hydroxy-1-(2-nitroimidazol-1-yl)cyclohexane

Cas No:143346-44-5

R&D Labs maybe for 143346-44-5

SuZhou Yacoo Science Co., Ltd

Contact:86-512-87182055

Address:No.128 Fangzhou Rd, Suzhou Industrial Park, China, 215125, China
Changsha Botaniex Inc.

Contact:(86) 731 88718666

Address:Room 1222, Unit 4, Building B, Shangcheng, No.47, Kaiyuan East Road.
Shanghai Norky Pharmaceutical Co., LTD.

website:http://www.norkypharm.com

Contact:86-21-61075300

Address:1165 Jiangning Road, Office 1502, Shanghai, China
Rayfull Holding Co., Ltd

Contact:+86-577-65618087-605

Address:Room 402, Unit 4 Xinhu Bldg. Waitan Ruian City, Zhejiang China.
Shandong Ailitong New Material Co.,Ltd

Contact:+86-536-3226266

Address:zhongjia village, putong town , qingzhou city,Shandong Province,China

Relevant to this article

Stereoselective synthesis of trans-4,5-disubstituted oxazolidin-2-ones by intramolecular conjugate addition of N-p-toluenesulfonyl carbamates

Doi:10.3987/com-03-9724
(2003)
Practical synthesis of precursor of [N-methyl-¹¹C]vorozole, an efficient PET tracer targeting aromatase in the brain

Doi:10.1016/j.bmc.2010.12.057
(2011)
PtCl₂-catalyzed tandem enyne cyclization/1,2 ester migration reaction controlled by substituent effects of all-carbon 1,6-enynyl esters

Doi:10.1002/asia.201300018
(2013)
Asymmetric synthesis of benzylic quaternary difunctionalized carbons mediated by a remote sulfinyl group

Doi:10.1021/jo2004204
(2011)
4-ANILINO-1,3-DIPHENYLIMIDAZOLIUM CHLORIDE

Doi:10.1007/BF00473878
(1989)
Cobalt(II) chloride catalysed condensation of acetoacetate with vinylethers

Doi:10.1016/S0040-4039(00)88839-5
(1990)

Article Doi