Synthesis and Pharmacological Characteization of 2-(4-Chloro-3-hydroxyphenyl)ethylamine and N,N-Dialkyl Derivatives as Dopamine Receptor Ligands

DOI: 10.1021/jm00101a018

Source and publish data:

Journal of Medicinal Chemistry p. 4408 - 4414 (1992)

Update date:2022-08-04

Topics:

Authors:

Claudi, Francesco

Giorgioni, Gianfabio

Stefano, Antonio Di

Abbracchio, Maria Pia

Paoletti, Anna Maria

et al. et al.

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Article abstract of DOI:10.1021/jm00101a018

2-(4-chloro-3-hydroxyphenyl)ethylamine (4) and some derivatives were synthesized as dopamine (DA) receptor ligands.Amine 4 retains the dopaminergic pharmacophore 2-(3-hydroxyphenyl)ethylamine, and the chlorine atom replaces the "para" hydroxyl group of DA

Full text of DOI:10.1021/jm00101a018

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