Regioselective chlorination at C-6 methyl position of 3,4-dihydropyrimidin- 2(1H)-ones using (dichloroiodo)benzene

Article abstract of DOI:10.1007/s00706-012-0908-0

The reaction of (dichloroiodo)benzene with 4-aryl-1,2,3,4-tetrahydro-6- methyl-2-oxopyrimidine-5-carboxylates and 5-acetyl-4-aryl-3,4-dihydro-6- methylpyrimidin-2(1H)-ones resulted in geminal dichlorination at the C-6 methyl position of 3,4-dihydropyrimid