Synthesis of isoquinoline alkaloids through a 10-membered lactam obtained by radical macrocyclisation

DOI: 10.1016/S0040-4039(00)61171-1

Source and publish data:

Tetrahedron Letters p. 5653 - 5654 (1992)

Update date:2022-08-04

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Authors:

Lamas, Carlos

Saa, Carlos

Castedo, Luis

Dominguez, Domingo

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Article abstract of DOI:10.1016/S0040-4039(00)61171-1

A new versatile method for the synthesis of isoquinoline alkaloids 3 and 5 is based on transannular cyclisation of a key macrocycle 2b obtained by an intramolecular addition of an aryl radical to a trimethylsilylacetylene.

Full text of DOI:10.1016/S0040-4039(00)61171-1

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Product name:Benzamide, N-[2-(2-bromophenyl)ethyl]-2-[(trimethylsilyl)ethynyl]-

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