The synthesis of (+)- and (-)-flesinoxan: Application of enzymatic resolution methodology

Article abstract of DOI:10.1016/S0040-4039(00)60954-1

The synthesis of (±)-flesinoxan was carried out in seven steps starting from catechol. An enzymatic resolution was utilized to prepare each enantiomer. Based upon the known preferences of the enzyme system used, we have assigned the (R)-configuration to the (+)-flesinoxan isomer.