Neuromuscular blocking agents. Some approaches to short acting compounds

Article abstract of DOI:10.1016/0223-5234(92)90180-9

A series of amidic and N-methylamidic methyl and trideuteromethyl quaternary analogues of atracurium have been prepared.All were less potent and longer acting neuromuscular blocking agents than atracurium, and all showed appreciable vagal blockade at neur