Journal of Medicinal Chemistry p. 3313 - 3326 (1994)
Update date:2022-08-04
Topics: Synthesis Structure-activity relationships Design X-ray Crystallographic Analysis
Bernstein, Peter R.
Andisik, Don
Bradley, Prudence K.
Bryant, Craig B.
Ceccarelli, Christopher
et al.
A series of nonpeptidic inhibitors of human leukocyte elastase (HLE) is reported.These trifluoromethyl ketone-based inhibitors contain a 3-amino-6-phenylpyridone group as a central template.The effect of varying the N-3 substituent in these inhibitors on
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Doi:10.3390/molecules13040749
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(1957)
