Nonpeptidic Inhibitors of Human Leukocyte Elastase. 3. Design, Synthesis, X-ray Crystallographic Analysis, and Structure-Activity Relationships for a Series of Orally Active 3-Amino-6-phenylpyridin-2-one Trifluoromethyl Ketones

DOI: 10.1021/jm00046a016

Source and publish data:

Journal of Medicinal Chemistry p. 3313 - 3326 (1994)

Update date:2022-08-04

Topics: Synthesis Structure-activity relationships Design X-ray Crystallographic Analysis

Authors:

Bernstein, Peter R.

Andisik, Don

Bradley, Prudence K.

Bryant, Craig B.

Ceccarelli, Christopher

et al. et al.

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Article abstract of DOI:10.1021/jm00046a016

A series of nonpeptidic inhibitors of human leukocyte elastase (HLE) is reported.These trifluoromethyl ketone-based inhibitors contain a 3-amino-6-phenylpyridone group as a central template.The effect of varying the N-3 substituent in these inhibitors on

Full text of DOI:10.1021/jm00046a016

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