Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 2. Modification of fatty acid anilide ACAT inhibitors: Bioisosteric replacement of the amide bond

Article abstract of DOI:10.1021/jm00063a016

In order to further define the structural features necessary for potent inhibition of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in vitro and cholesterol lowering in vivo, a systematic study of bioisosteric replacements for the amide bond in our p