Oligonucleotides Derived from 5-(1-Propynyl)-2'-O-Allyl-Uridine and 5-(1-Propynyl)-2'-O-Allyl-Cytidine: Synthesis and RNA Duplex Formation

DOI: 10.1016/S0040-4039(00)77476-4

Source and publish data:

Tetrahedron Letters p. 1003 - 1006 (1993)

Update date:2022-07-30

Topics:

Authors:

Froehler, Brian C.

Jones, Robert J.

Cao, Xiaodong

Terhorst, Terry J.

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Article abstract of DOI:10.1016/S0040-4039(00)77476-4

The protected nucleoside analogs of 5-(1-propynyl)-2'-O-allyl-uridine and 5-(1-propynyl)-2'-O-allyl-cytidine are described.Oligonucleotides containing this modification significantly enhance double-helix formation with single-strand RNA.

Full text of DOI:10.1016/S0040-4039(00)77476-4

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