European Journal of Medicinal Chemistry p. 63 - 69 (1993)
Update date:2022-08-04
Topics:
Anderson, B.
Wikstroem, H.
Hjorth, S.
Svensson, K.
Carlsson, A.
et al.
A series of cis- and trans-2-arylcyclohexylamines were synthesized and resolved.The absolute configuration was determined by single-crystal X-ray analysis.Some of the compounds, and especially racemic 2-(3-hydroxyphenyl)-N,N-dipropylcyclohexylamine showed a marked locomotor stimulation in reserpinized rats.However, these compounds displayed only minor effects on dopamine and 5-hydroxytryptamine synthesis rates, indicating a non-dopaminergic and/or serotonergic mechanism for this stimulation. Keywords: 2-arylcyclohexylamines / dopamine / 5-hydroxytryptamine (5-HT) / locomotor stimulation / reserpinized rats / X-ray analysis
View MoreWuxi Innopal International Trade CO.,LTD
Contact:+86-510-80711901-8003
Address:Room 402,Building 5,Longze Garden,No.17,South huanjiu Road,Yixing City, Jiangsu,China
Shanghai Puda Chemical Co.,Ltd
Contact:+86+571+56565965
Address:10F Haiyue Building,Danfeng Road,Binjiang District,Hangzhou,China
NIGNXIA XINDACHANG TECHNOLOGY CO.,LTD
Contact:86-0951-7815345
Address:North side of Qiyuan Road, west side of Yuanfeng Highway, New Material Park, Ningdong Energy and Chemical Industry Base, Ningxia,China
Xinji City Taida Sinopec Co., Ltd.
Contact:0086-311-85341278
Address:No.6, Nanhua Road,Xinji City Road,Hebei Province,China
Hubei Lansun Biochemical Pharmaceutical Co., Ltd
Contact:714-6395977
Address:No. 81 Pengcheng Avenue, economic and technological development zone, Huangshi City, Hubei Province,China
Doi:10.1016/0022-328X(93)80138-2
(1993)Doi:10.3987/COM-15-13340
(2015)Doi:10.1021/ol991383c
(2000)Doi:10.1039/P19930002251
(1993)Doi:10.1016/S0040-4020(01)96674-8
(1985)Doi:10.1021/om00128a010
(1985)
