European Journal of Medicinal Chemistry p. 63 - 69 (1993)
Update date:2022-08-04
Topics:
Anderson, B.
Wikstroem, H.
Hjorth, S.
Svensson, K.
Carlsson, A.
et al.
A series of cis- and trans-2-arylcyclohexylamines were synthesized and resolved.The absolute configuration was determined by single-crystal X-ray analysis.Some of the compounds, and especially racemic 2-(3-hydroxyphenyl)-N,N-dipropylcyclohexylamine showed a marked locomotor stimulation in reserpinized rats.However, these compounds displayed only minor effects on dopamine and 5-hydroxytryptamine synthesis rates, indicating a non-dopaminergic and/or serotonergic mechanism for this stimulation. Keywords: 2-arylcyclohexylamines / dopamine / 5-hydroxytryptamine (5-HT) / locomotor stimulation / reserpinized rats / X-ray analysis
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