Biocatalytic resolution of DL-propranolol. A successful example of computer-aided substrate design

Article abstract of DOI:10.1016/S0040-4020(01)90157-7

An approach entailing computer-aided substrate design was taken to develop biocatalytic resolution of racemic propranolol. This strategy provided useful insight into potential steric factors within the substrate, which might be crucial to the catalytic turnover and enantiomeric selection.