Tetrahedron p. 4283 - 4292 (1993)
Update date:2022-07-30
Topics:
Afonso, Carlos A. M.
Teresa Barros
Godinho, Licio S.
Maycock, Christopher D.
A synthesis of all four stereoisomers of 4-hydroxy-5-methyl-2(3H)-dihydrofuranone was achieved in 6 or 7 steps with an overall yield of 19% to 23% from a common starting material. The source of chirality being derived from stereoselective bakers' yeast reductions of carbonyl groups.
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