A concise synthesis of the novel antibiotic aranorosin

Article abstract of DOI:10.1016/S0040-4039(00)73870-6

A short synthesis of the novel antibiotic aranorosin is described which employs a novel hypervalent iodine-mediated oxidative hydroxylation of a tyrosinal derivative in the key step. A similar procedure was employed to prepare 6'-epiaranorosin, and hence establish the stereochemistry of the natural compound.