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Basic Information
CAS No.: 157115-85-0
Name: ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate
Article Data: 1
Molecular Structure:
Molecular Structure of 157115-85-0 (ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate)
Formula: C17H22N2O4
Molecular Weight: 318.373
Synonyms: Glycine,1-(phenylacetyl)-L-prolyl-, ethyl ester (9CI);Glycine,N-[1-(phenylacetyl)-L-prolyl]-, ethyl ester;GVS 111;Glycine,1-(2-phenylacetyl)-L-prolyl-, ethyl ester;SGS 111;Glycine, 1-(phenylacetyl)-L-prolyl-, ethyl ester;
EINECS: 1592732-453-0
Density: 1.202g/cm3
Melting Point: 94.0 to 98.0 °C
Boiling Point: 547.3°Cat760mmHg
Flash Point: 284.8°C
Appearance: white powder
PSA: 75.71000
LogP: 1.22820
Synthetic route
623-33-6

glycine ethyl ester hydrochloride

C18H23NO4

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

Conditions
ConditionsYield
With 4-methyl-morpholine In chloroform; N,N-dimethyl-formamide at -5 - 20℃; for 1.5h; Yield given;
2752-38-7

(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C
2: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C
View Scheme
103-80-0

phenylacetyl chloride

lead (II)-compound of ethanethiol

lead (II)-compound of ethanethiol

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 86 percent / aq. NaOH / 0.25 h / 0 - 4 °C
2: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C
3: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C
View Scheme
147-85-3

L-proline

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 86 percent / aq. NaOH / 0.25 h / 0 - 4 °C
2: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C
3: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C
View Scheme
74-89-5

methylamine

157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

N-phenylacetyl-L-prolylglycine methylamine

Conditions
ConditionsYield
In methanol Ambient temperature;99%
157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

N-phenylacetyl-L-prolylglycine amide

Conditions
ConditionsYield
With ammonia In methanol Ambient temperature;95%
157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

157115-95-2

N-phenylacetyl-L-prolylglycine

Conditions
ConditionsYield
With sodium hydroxide for 3h;89.9%
157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

N-phenylacetyl-L-prolylglycine dimethylamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 89.9 percent / 1 N aq. NaOH / 3 h
2: ethylmorpholine / dimethylformamide / 0.03 h / -10 °C
3: dimethylformamide / 0.5 h / -5 °C
View Scheme
157115-85-0

N-phenylacetyl-L-prolylglycine ethyl ester

C20H26N2O6

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89.9 percent / 1 N aq. NaOH / 3 h
2: ethylmorpholine / dimethylformamide / 0.03 h / -10 °C
View Scheme
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157115-95-2
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    PRODUCT DETAILS Noopept Basic information Product Name: Noopept Synonyms: Noopept;ethyl 2-[[(2S)-1-(2-phenylacet

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  • 1-(2-phenylacetyl)-L-prolyl-Glycine ethyl ester

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Chemistry

IUPAC Name: Ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate
Synonyms of Noopept (CAS NO.157115-85-0): ethyl phenylacetyl-Pro-Gly ;  GVS 111 ; GVS-111 ; Glycine, N-(1-(phenylacetyl)-L-prolyl)-, ethyl ester ; Glycine, 1-(phenylacetyl)-L-prolyl-, ethyl ester
CAS NO: 157115-85-0
Classification Code: Nootropic
Molecular Formula of Noopept (CAS NO.157115-85-0): C17H22N2O4
Molecular Weight: 318.3676
Molecular Structure:

Polar Surface Area: 66.92 Å2
Index of Refraction: 1.548
Molar Refractivity: 84.17 cm3
Molar Volume: 264.7 cm3
Surface Tension: 49.7 dyne/cm
Density: 1.202 g/cm3
Flash Point: 284.8 °C
Enthalpy of Vaporization: 82.67 kJ/mol
Boiling Point: 547.3 °C at 760 mmHg
Vapour Pressure: 4.93E-12 mmHg at 25°C

Uses

 Noopept (CAS NO.157115-85-0) is a drug promotion. It is from the drugs and share similar mechanisms of action, racetam family income, but up to 1,000 times higher than the prototype racetam potent drug, piracetam. Animal studies have shown noopept is to protect and enhance neurological test different memory. Unusual is that peptides derived compounds, noopept also showed oral bioavailability and good blood-brain barrier permeability, and human studies have shown promising and the treatment of Alzheimer's disease has a potential application of the results.