CAS No.9067-32-7,Hyaluronicacid, sodium salt Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	9067-32-7
Name:	Hyaluronicacid, sodium salt
Article Data:	2
Cas Database

Formula:	(C₁₄H₂₀NO₁₁Na)_n
Molecular Weight:	N/A
Synonyms:	Arthrease;Artz Dispo;Artzal;Bio Hyaluro 12;Chlamyhyaluronic acid sodium salt;Cystistat;FCH 121-S;FCH 200;FCH 248;FCH 60;FCH 80;FCH-SU;Fermatron;HA-F;HA-Q;HA-Q 1;HA-QA;Hyaluronate sodium inj;Hyaluronate sodium;HE-QSE;Healon;Healon (polysaccharide);Healon GV;Healon V;Hyalart;Hyalein;Hyalgan;Hyaluronsan HA-LQ;Hyaluronsan HA-LQ1;Hyaluronsan HA-LQH;Hyaluronsan HA-Q;Hyaluronsan HA-QSS;Hyaluronsan M 5070;Hyasol;Hyasol BT;Hyladerm;Khionat;NRD 101;Nidelon;Opegan;Orthovisc;Ostenil;Provisc;SI 4402;SL 1010;SLM 10;SPH;Sinovial;Sodium hyaluronate;Suvenyl;
EINECS:	232-678-0
Density:	1.78g/cm3
Melting Point:	N/A
Boiling Point:	791.6oC
Flash Point:	432.5oC
Solubility:	soluble in water
Appearance:	solid
Hazard Symbols:	B,Xi
Risk Codes:	36/37/38
Safety:	22-24/25
Transport Information:	N/A
PSA:	399.71000
LogP:	-8.49480

Raw Materials

9004-61-9

Downstream Products

9004-61-9

Total:319 Page 1 of 9 1 2 3 4 5 6 …9 Next>>

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Specification

Sodium hyaluronate is the sodium salt of hyaluronan. With the CAS NO. 9067-32-7, it is a visco-elastic polymer normally found in the aqueous and vitreous humour. It is also called Arthrease, Bio Hyaluro 12 , CCRIS 4127, Chlamyhyaluronic acid sodium salt. Sodium hyaluronate is a viscous solution consisting of a high molecular weight (500,000-730,000 daltons) fraction of purified natural sodium hyaluronate in buffered physiological sodium chloride. We should keep container tightly closed and keep container in a cool, well-ventilated area. Do not store above 8^°C (46.4^°F). Refrigerate. Store at tempertures from 2 - 8 ^°C.

Physical properties about Sodium hyaluronate are: (1)ACD/LogP: -1.131; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): -3.85; (4)ACD/LogD (pH 7.4): -4.83; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 12; (10)#H bond donors: 7; (11)#Freely Rotating Bonds: 10; (12)Flash Point: 432.5 °C; (13)Enthalpy of Vaporization: 131.19 kJ/mol; (14)Boiling Point: 791.6 °C at 760 mmHg; (15)Vapour Pressure: 5.77E-29 mmHg at 25°C

Uses of Sodium hyaluronate: Sodium hyaluronate is used as a viscosupplement, administered through a series of injections into the knee, increasing the viscosity of the synovial fluid, which helps lubricate, cushion and reduce pain in the joint. It is generally used as a last resort before surgery and provides symptomatic relief, by recovering the viscoelasticity of the articular fluid, and by stimulating new production from synovial fluid.

When you are using Sodium hyaluronate, please be cautious about it as the following:
1. Do not breathe dust;
2. Avoid contact with skin and eyes;
3. Wear suitable protective clothing, gloves and eye/face protection;
4. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
5. Take off immediately all contaminated clothing;

You can still convert the following datas into molecular structure:

(1)InChI=1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1;
(2)InChIKey=YWIVKILSMZOHHF-QJZPQSOGSA-N;
(3)Smiles[Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1O[C@@H]1O[C@@H]([C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@@H](O[C@@H]3O[C@@H]([C@@H](O)[C@@H](O)[C@H]3O)C(O)=O)[C@H]2NC(C)=O)[C@@H](O)[C@H]1O)C(O)=O;

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	subcutaneous	> 50mg/kg (50mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl,
mouse	LD50	intraperitoneal	1500mg/kg (1500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 1013, 1984.
mouse	LD50	oral	> 2400mg/kg (2400mg/kg)		Drugs in Japan Vol. -, Pg. 849, 1990.
mouse	LD50	subcutaneous	> 4gm/kg (4000mg/kg)	BEHAVIORAL: ATAXIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rabbit	LD50	intraperitoneal	1820mg/kg (1820mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BLOOD: NORMOCYTIC ANEMIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rabbit	LD50	oral	> 1gm/kg (1000mg/kg)		Drugs in Japan Vol. -, Pg. 849, 1990.
rabbit	LD50	subcutaneous	> 2gm/kg (2000mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rabbit	LD50	subcutaneous	> 2gm/kg (2000mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rat	LD50	intraperitoneal	1770mg/kg (1770mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BLOOD: NORMOCYTIC ANEMIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rat	LD50	oral	> 800mg/kg (800mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rat	LD50	subcutaneous	> 4gm/kg (4000mg/kg)	BEHAVIORAL: ATAXIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.

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