The Synthesis of a C1-C8 Lactone Fragment of Discodermolide

Article abstract of DOI:10.1016/S0040-4039(00)61479-X

The asymmetric synthesis of a fragment corresponding to the C₁-C₈ region of the immunosuppressant discodermolide is reported.A trihydroxylactone of defined absolute stereochemistry is also prepared.This compound is a potential reductive ozonolysis product of discodermolide and may aid the determination of the absolute stereochemistry of the natural product.