Microbial Synthesis of (2R,3S)-(-)-N-benzoyl-3-phenyl isoserine ethyl ester-a taxol side-chain synthon

Article abstract of DOI:10.1016/S0957-4166(00)82256-9

The chiral intermediate (2R,3S)-(-)-N-benzoyl-3-phenyl isoserine ethyl ester 2a, a potential taxol 5 side-chain synthon, was prepared by microbial and enzymatic processes.Taxol 5, is an anticancer compound recently approved by FDA for the treatment of ova