Journal of Organic Chemistry p. 7507 - 7515 (1993)
Update date:2022-08-04
Topics:
Snyder, Lawrence
Meyers, A. I.
A route to the titled compounds in >99percent ee was achieved from sequential diastereoselective alkylations of chiral, nonracemic bicyclic lactams 6 and 15.An intramolecular addition of the organolithium species derived from 17a-c and 28a-d gave, after hydrolysis, diketones 25a-c and 30a-d, which were cyclized to the titled compounds 4a-c and 31a-d.As an example of the versatility of this method, the ABC ring system of the triterpene stelliferin A, isolated from marine organisms, was prepared in high enantiomeric excess.
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