Cytotoxicity and Antiviral Activity of Transition-metal Salicylato Complexes and Crystal Structure of Bis(diisopropylsalicylato)(1,10-phenanthroline)copper(II)

DOI: 10.1039/DT9930003393

Source and publish data:

Journal of the Chemical Society, Dalton Transactions p. 3393 - 3400 (1993)

Update date:2022-08-04

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Authors:

Ranford, John D.

Sadler, Peter J.

Tocher, Derek A.

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Article abstract of DOI:10.1039/DT9930003393

Complexes of Cu(II), Fe(III), Co(II), Ni(II), Ti(IV) and Zn(II) with 3,5-disubstituted salicylates, and ternary complexes of Cu(II) containing substituted phenanthrolines have been prepared and characterised.The crystal structure of bis(diisopropylsalicylato)(1,10-phenanthroline)copper(II), , has been determined; Cu(II) is in a tetragonal co-ordination environment with in-plane bonds to 2 nitrogens from phen and 2 oxygens from the carboxylates of Hdips , with weaker off-axial bonds to carboxylate oxygens .The hydroxyl oxygen of Hdips is not co-ordinated.These complexes have been tested for antiviral and cytotoxic activity.Most are potently cytotoxic, especially , where dmphen is 2,9-dimethylphenanthroline.

Full text of DOI:10.1039/DT9930003393

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