Tetrahedron p. 10027 - 10048 (1993)
Update date:2022-09-26
Topics:
Rutjes
Hiemstra
Pirrung
Speckamp
Bicyclic molecules with the 1,7-diaza-6,6-dimethylbicyclo[2.2.1]heptane and 1,8-diaza-7,7-dimethylbicyclo[3.2.1]octane (1-aza-7,7-dimethytropane) skeleton are shown to be efficiently synthesized via cyclization reactions of endocyclic N-acylhydrazonium intermediates. By using a protected β-ketoester as the internal nucleophile, azacocaine analogues are also accessible via this methodology.
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Doi:10.1021/jo402661b
(2014)Doi:10.1021/ja0450509
(2004)Doi:10.1016/S0040-4039(00)75783-2
(1994)Doi:10.1016/j.bmc.2013.12.055
(2014)Doi:10.1021/ja412634w
(2014)Doi:10.1039/jr9490002656
(1949)
