A Free Radical Route to Syn Lactones and other Prostanoid Intermediates in Isoprostaglandin Synthesis.

DOI: 10.1016/S0040-4039(00)61401-6

Source and publish data:

Tetrahedron Letters p. 8245 - 8248 (1993)

Update date:2022-08-02

Topics:

Authors:

Rondot, Benoit

Durand, Thierry

Girard, Jean Pierre

Rossi, Jean Claude

Schio, Laurent

et al. et al.

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Article abstract of DOI:10.1016/S0040-4039(00)61401-6

The hex-5-enyl radical cyclization methodology was applied to the formation of optical active prostanoid intermediates 7,8,9 with readily available diacetone-D-glucose as starting material.This result should lead to isoprostaglandins, a novel class of arachidonic acid metabolites obtained by a non-cyclooxygenase mechanism involving free radical-catalysed peroxidation of arachidonic acid.

Full text of DOI:10.1016/S0040-4039(00)61401-6

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