6-Alkyl- and 6-Arylandrost-4-ene-3,17-diones as Aromatase Inhibitors. Synthesis and Structure-Activity Relationships

DOI: 10.1021/jm00035a011

Source and publish data:

Journal of Medicinal Chemistry p. 1312 - 1319 (1994)

Update date:2022-08-02

Topics:

Authors:

Numazawa, Mitsuteru

Oshibe, Mariko

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Article abstract of DOI:10.1021/jm00035a011

Two series of 6β- and 6α-substituted androst-4-ene-3,17-diones (5 and 6) were synthesized as aromatase inhibitors to gain insights of structure-activity relationships of varying substituents (methyl, ethyl, n-propyl, isopropyl, n-butyl, phenyl, benzyl, vi

Full text of DOI:10.1021/jm00035a011

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