An Efficient Synthesis of Polyoxamic Acid Utilizing the Aryl Group as the Carboxyl Synthon. A New Approach to Polyhydroxyamino Acids.

DOI: 10.1016/S0040-4039(00)75803-5

Source and publish data:

Tetrahedron Letters p. 733 - 736 (1994)

Update date:2022-07-30

Topics:

Authors:

Matsuura, Fumiyoshi

Hamada, Yasumasa

Shioiri, Takayuki

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Article abstract of DOI:10.1016/S0040-4039(00)75803-5

Polyoxamic acid (1), an amino acid moiety of antifungal antibiotics polyoxins, has been efficiently synthesized from Boc-(R)-4-hydroxyphenylglycine (3) utilizing its aryl group as the carbonyl synthon.

Full text of DOI:10.1016/S0040-4039(00)75803-5

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