The Total Synthesis of Swinholide A. Part 3: A Stereocontrolled Synthesis of (-)-Pre-Swinholide A.

DOI: 10.1016/0040-4020(95)00548-M

Source and publish data:

Tetrahedron p. 9437 - 9466 (1995)

Update date:2022-07-30

Topics:

Authors:

Paterson, Ian

Ward, Richard A.

Smith, Julian D.

Cumming, John G.

Yeung, Kap-Sun

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Article abstract of DOI:10.1016/0040-4020(95)00548-M

Two coupling strategies for (-)-pre-swinholide A were devised based on the analysis in Scheme 1.In the first route, a boron-mediated aldol reaction between the ethyl ketone 19 and the aldehyde 3 was used to construct the C15-C16 bond with moderate diaster

Full text of DOI:10.1016/0040-4020(95)00548-M

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