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| CAS No.: | 74150-27-9 |
|---|---|
| Name: | Pimobendan |
| Molecular Structure: | |
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| Formula: | C19H18N4O2 |
| Molecular Weight: | 334.378 |
| Synonyms: | Acardi;Racemic pimobendan;UD-CG 115;UD-CG 115BS;Vetmedin;3(2H)-Pyridazinone,4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl- (9CI); |
| EINECS: | 640-420-7 |
| Density: | 1.36 g/cm3 |
| Melting Point: | approximate 243℃ (dec.) |
| Hazard Symbols: |
 Xi
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| Risk Codes: | R36/37/38 |
| PSA: | 79.37000 |
| LogP: | 2.86300 |
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Empirical Formula: C19H18N4O2
Molecular Weight: 334.3718
Nominal Mass: 334 Da
Average Mass: 334.3718 Da
Monoisotopic Mass: 334.142976 Da
Index of Refraction: 1.692
Molar Refractivity: 94 cm3
Molar Volume: 245.2 cm3
Surface Tension: 51.7 dyne/cm
Density: 1.36 g/cm3
Structure of Pimobendan (CAS NO.74150-27-9):
IUPAC Name: 3-[2-(4-Methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one
Canonical SMILES: CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC
InChI: InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
InChIKey: GLBJJMFZWDBELO-UHFFFAOYSA-N
Product Category of Pimobendan (CAS NO.74150-27-9): Pharmaceutical intermediates; cardiac drugs; cardiovascular drugs
Pimobendan (CAS NO.74150-27-9) has strong positive inotropic effect and a strong vasodilator and platelet aggregation, and is used for the treatment of chronic and acute heart failure. It is used in the management of heart failure in dogs, most commonly caused by myxomatous mitral valve disease (also known as endocardiosis), or dilated cardiomyopathy.
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| monkey | LD50 | oral | > 2gm/kg (2000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 25, Pg. 815, 1994. | |
| mouse | LD50 | oral | > 2gm/kg (2000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 561, 1992. | |
| rat | LD50 | intravenous | 72mg/kg (72mg/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: OTHER CHANGES | Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 561, 1992. |
| rat | LD50 | oral | 950mg/kg (950mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES ENDOCRINE: OTHER CHANGES | Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 561, 1992. |
| rat | LD50 | subcutaneous | > 300mg/kg (300mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 25, Pg. 815, 1994. |
Pimobendan , its cas register number is 74150-27-9. It also can be called Pimobendane ; dl-Pimobendan ; and 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone . It is a positive inotrope, and sensitizes and increases the binding efficiency of cardiac myofibril to the calcium ions that are already present without increasing the consumption of oxygen and energy. It is metabolized into its active form by the liver, and is absorbed rapidly when given via the oral route and has a bioavailability of 60-65%.
