Nucleosides and Nucleotides p. 859 - 862 (1995)
Update date:2022-07-29
Topics:
Sanghvi
Cook
An efficient synthesis of a thymidine nucleoside dimer [T-3'-β-O- N(CH3)-CH2-5'-T] has been accomplished via an intermolecular radical coupling reaction. The novel dimer contains an achiral and neutral backbone linkage which may have potential application in constructing backbone modified antisense oligonucleosides.
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Doi:10.1021/ol403716t
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(1996)