Facile synthesis of a simplified bicyclo[7.3.1] esperamicin-calicheamicin enediyne core

DOI: 10.1016/S0040-4020(01)80632-3

Source and publish data:

Tetrahedron p. 1519 - 1538 (1994)

Update date:2022-08-05

Topics:

Authors:

Kadow, John F.

Cook, Donald J.

Doyle, Terrence W.

Langley, David R.

Pham, Kahnie M.

Vyas, Dolatrai M.

Wittman, Mark D.

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Article abstract of DOI:10.1016/S0040-4020(01)80632-3

An efficient non cobalt mediated route for the synthesis of a simplified bicyclo[7.3.1]enediyne core of the naturally occurring calicheamicins and esperamicins is described. The key cyclization provides a single propargylic alcohol stereoisomer which is i

Full text of DOI:10.1016/S0040-4020(01)80632-3

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