Journal of the American Chemical Society p. 8593 - 8601 (1994)
Update date:2022-08-05
Berk, Scott C.
Grossman, Robert B.
Buchwald, Stephen L.
The first early transition metal-catalyzed enyne cyclization reaction is described. The system converts enyne substrates to bicyclic iminocyclopentenes through the use of 10 mol % of Cp2Ti(PMe3)2 in the presence of a silyl cyanide. Subsequent hydrolysis produces the corresponding bicyclic cyclopentenones in good overall yield. The cyclization reaction is tolerant of polar functional groups such as ethers, amines, and esters and is diastereoselective with certain chiral enyne substrates.
View Morewebsite:http://www.sigmaaldrich.com
Contact:800 558-9160
Address:Industriestrasse 25CH-9471 Buchs SGSwitzerland
Huangshan Violet Biological Technology Co., Ltd
Contact:+86-559-2335676
Address:16-201 JinShanYuan,JiangNan New City,TunXi District,HuangShan City,AnHui Province,China
Tianjin Emulsion Science&Technology Development Co.,Ltd
Contact:13901380442
Address:Vake Garden New Town New Yi Bai Road Beichen District Tianjin,China
Daicel Chiral Technologies (China)CO.,LTD
Contact:021-5046-0086*8
Address:Part C, FL 5, the 16th Building, No. 69, XiYa Road, WaiGaoQiao Free Trade Zone, Shanghai, 200131, P.R.China
Ji'nan Orgachem Pharmaceutical Co.,Ltd
Contact:+86-531-82687810
Address:Jinan
Doi:10.1021/ml500015r
(2014)Doi:10.1016/j.poly.2014.01.035
(2014)Doi:10.1016/j.ejmech.2018.03.014
(2018)Doi:10.1007/BF00683835
(1969)Doi:10.1023/B:CONC.0000033927.92754.bd
(2004)Doi:10.1021/ja00318a053
(1984)
