6433-72-3

Basic information

• Product Name: ETHYL 2-AMINOINDOLE-3-CARBOXYLATE
• Synonyms: ETHYL 2-AMINOINDOLE-3-CARBOXYLATE;2-AMINOINDOLE-3-CARBOXYLIC ACID, ETHYL ESTER;ethyl 2-aminoindoline-3-carboxylate;2-AMINOINDOLE-3-CARBOXYLIC ETHYL ESTER;1H-Indole-3-carboxylicacid,2-amino-,ethylester(9CI);1H-Indole-3-carboxylicacid, 2-amino-, ethyl ester
• CAS NO: 6433-72-3
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.23
• Product Categories: AMINOACID;Indole Derivatives
• Mol File: 6433-72-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 178-180°C
• Boiling Point: 400.1 °C at 760 mmHg
• Flash Point: 195.8 °C
• Appearance: Off-White Crystalline Solid
• Density: 1.288 g/cm³
• Vapor Pressure: 1.3E-06mmHg at 25°C
• Refractive Index: 1.669
• Storage Temp.: -20°C Freezer
• Solubility: Benzene, DMSO, Methanol
• PKA: 17.31±0.30(Predicted)
• CAS DataBase Reference: ETHYL 2-AMINOINDOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-AMINOINDOLE-3-CARBOXYLATE(6433-72-3)
• EPA Substance Registry System: ETHYL 2-AMINOINDOLE-3-CARBOXYLATE(6433-72-3)

Safety Data

• Hazardous Substances Data: 6433-72-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Crystalline Solid

Uses

Ethyl 2-Aminoindole-3-carboxylate (cas# 6433-72-3) is a compound useful in organic synthesis.

InChI:InChI=1/C11H12N2O2/c1-2-15-11(14)9-7-5-3-4-6-8(7)13-10(9)12/h3-6,13H,2,12H2,1H3

Upstream product

• 2727-71-1 N-(2-bromophenyl)-2,2,2-trifluoroacetamide 
• 105-56-6 ethyl 2-cyanoacetate 
• 143321-89-5 2,2,2-trifluoro-N-(2-iodophenyl)acetamide 
• 88-73-3 2-Chloronitrobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 10113-39-0 N-formyl-2-iodoaniline 
• 615-43-0 2-iodophenylamine 
• 65548-02-9 (+/-)-ethyl cyano(2-nitrophenyl)acetate 
• 65547-91-3 2-amino-1-hydroxy-indole-3-carboxylic acid ethyl ester 

Downstream Products

• 654675-14-6 10-methyl-3-phenyl-4H-indolo[3,2-e][1,2,3]triazolo[1,5-a]pyrimidin-5(10H)-one 
• 1432509-70-0 methyl 4-((4-oxo-3,4-dihydropyrimido[4,5-b]indol-9-yl)methyl)benzoate 
• 1432508-53-6 N-hydroxy-4-((4-oxo-3,4-dihydropyrimido[4,5-b]indol-9-yl)methyl)benzamide 
• 1350516-27-6 2,4-bis(4-methylphenyl)-9H-pyrido[2,3-b]indole 
• 1324007-09-1 ethyl 2-(4-methylphenyl)-4-phenylpyrimido[1,2-a]indole-10-carboxylate 
• 1350516-28-7 4-[4-(tert-butyl)phenyl]-2-(4-methylphenyl)-9H-pyrido[2,3-b]indole 

Relevant articles and documents

Synthesis of 2-amino-3-carbethoxy-1-hydroxyindoles

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HYDROXAMATE DERIVATIVES FOR HDAC INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THEREOF

The present invention relates to a novel hydroxamate derivatives, more specifically, to novel hydroxamate derivatives having inhibitory activity against Histone Deacetylase (HDAC), isomers thereof, pharmaceutically acceptable salts thereof, hydrates or solvates thereof, use for preparing pharmaceutical compositions, pharmaceutical compositions comprising the same, treatment method using said composition, and a preparing method of novel hydroxamate derivatives. The novel selective hydroxamate derivatives having inhibitory activity against Histone Deacetylase (HDAC) compositions can be used for treatment of inflammatory disease, rheumatoid arthritis, or degenerative disease.

Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4, 5-b]indole ribonucleoside with (het)arylboronic acids or stannanes followed by deprotection. Further cross-couplings under harsher conditions and employing X-Phos ligand proceeded at the position 6 leading to 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides. Some of these compounds displayed antiviral activity against Dengue virus.