Synthesis of (R)- and (S)-4'-acetoxyolivetol [(R)- and (S)-5-(4'-acetoxypentyl)-1,3-benzenediol]: Key intermediates in the synthesis of tetrahydrocannabinol derivatives

Article abstract of DOI:10.1055/s-1994-25509

The synthesis of (R)- and (S)-4'-acetoxyolivetols, key intermediates in the synthesis of tetrahydrocannabinol derivatives from 3,5-dihydroxybenzoic acid (4) is described. The 3,5-dihydroxy groups were protected as their tert-butyldimethylsilyl derivatives