Synthesis and Structure-Activity Studies on Acidic Amino Acids and Related Diacids as NMDA Receptor Ligands

Article abstract of DOI:10.1021/jm00046a009

The 3-isoxazolol amino acids (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid <(S)-AMPA,2> and (R,S)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid (AMAA,5a) (Figure 1) are potent and specific agonists at the AMPA and N-methyl-D-aspar