Synthesis, NMDA receptor antagonist activity, and anticonvulsant action of 1-aminocyclobutanecarboxylic acid derivatives

DOI: 10.1021/jm00051a005

Source and publish data:

Journal of Medicinal Chemistry p. 4288 - 4296 (1994)

Update date:2022-08-03

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Authors:

Gaoni Gaoni

Chapman Chapman

Parvez Parvez

Pook Pook

Jane Jane

Watkins Watkins

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Article abstract of DOI:10.1021/jm00051a005

A range of cis- and trans-3-substituted 1-aminocyclobutane-1-carboxylic acids has been synthesized and evaluated for antagonism at excitatory amino acid receptor sites and for anticonvulsant activity. Potent and selective antagonist activity at N-methyl-D

Full text of DOI:10.1021/jm00051a005

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