3-Amino-5,5-dimethylhexanoic acid. Synthesis, resolution, and effects on carnitine acyltransferases

DOI: 10.1021/jm00046a008

Source and publish data:

Journal of Medicinal Chemistry p. 3247 - 3251 (1994)

Update date:2022-08-05

Topics:

Authors:

Saeed Saeed

McMillin

Wolkowicz

Brouillette

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00046a008

The selective inhibition of individual carnitine acyltransferases may be useful in the therapy of diabetes and heart disease. Aminocarnitine (3) is a weak competitive inhibitor (K(i) = 4.0 mM) for carnitine acetyltransferase (CAT), although the N-acetyl d

Full text of DOI:10.1021/jm00046a008

Products guided by the article

Product name:(3S,2'R)-ethyl 3-(2-methoxy-2-phenylacetamido)-5,5-dimethylhexanoate

Cas No:158362-77-7

R&D Labs maybe for 158362-77-7

Linyi VIHO Chemical Co.,Ltd

Contact:86-15588110016

Address:LINYI CITY,SHANDONG PROVINCE,CHINA
Kaiping Genuine Biochemical Pharmaceutical Co.,Ltd.

Contact:+86-750-2881198

Address:No.1, Xinke Road, Shatang Town, Kaiping, Guangdong Province, P.R.China
SHANGHAI T&W PHARMACEUTICAL CO., LTD.

website:http://www.trustwe.com

Contact:+86-21-61551413

Address:601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong
Tianjin Te-An Chemtech Co., Ltd.(expird)

Contact:+86-22-65378638

Address:A5-8, No.80 Haiyun Street, TEDA
Accendatech Co., LTD

Contact:+86-22-83718541

Address:32th Floor, Rongqiao Center Intersection of Changjiang Road and Nankai Six Road Nankai District Tianjin 300102, China

Relevant to this article

Synthesis and structure-activity relationships of 7β-[(Z)-2-(2-aminothiazol-4-yl)-3-(substituted)-2- propenoyl-amino]-3-cephems with C-3 substitutions

Doi:10.7164/antibiotics.47.466
(1994)
Oleanane glycosides from Eclipta alba

Doi:10.1248/cpb.42.1336
(1994)
Tandem Insertion/[3,3]-Sigmatropic Rearrangement Involving the Formation of Silyl Ketene Acetals by Insertion of Rhodium Carbenes into S-Si Bonds

Doi:10.1021/acs.orglett.1c00229
(2021)
Relative and Absolute Stereochemistry of the Fumonisin B₂ Backbone

Doi:10.1016/0040-4039(94)85013-5
(1994)
An expedient four-component domino protocol for the regioselective synthesis of highly functionalized pyranopyrazoles and chromenopyrazoles via nitroketene-N,S-acetal chemistry under solvent-free condition

Doi:10.1016/j.tetlet.2014.02.019
(2014)
Slow and fast singlet energy transfers in BODIPY-gallium(III)corrole dyads linked by flexible chains

Doi:10.1021/ic402798f
(2014)

Article Doi