3-Amino-5,5-dimethylhexanoic acid. Synthesis, resolution, and effects on carnitine acyltransferases

DOI: 10.1021/jm00046a008

Source and publish data:

Journal of Medicinal Chemistry p. 3247 - 3251 (1994)

Update date:2022-08-05

Topics:

Authors:

Saeed Saeed

McMillin

Wolkowicz

Brouillette

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Article abstract of DOI:10.1021/jm00046a008

The selective inhibition of individual carnitine acyltransferases may be useful in the therapy of diabetes and heart disease. Aminocarnitine (3) is a weak competitive inhibitor (K(i) = 4.0 mM) for carnitine acetyltransferase (CAT), although the N-acetyl d

Full text of DOI:10.1021/jm00046a008

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