Deoxyoligonucleotides containing 2′ ,5′ acetal linkages: Synthesis and hybridization properties

Article abstract of DOI:10.1016/S0040-4039(00)78530-3

Two 3′-deoxy-5-methyluridine-3′-deoxy-5-methyluridine dimers interconnected by 2′,5′ formacetal 3 and thioformacetal 4 were synthesized and incorporated into oligonucleotides. The 2′,5′ thioformacetal derivative resulted in substantial destabilization of