A Facile Synthesis of 2-Substituted N-tert-Butoxycarbonyl-N-methyl-1,3-propanediamines, Key Intermediates for the Preparation of Triplex DNA-Specific Intercalators

DOI: 10.1016/0040-4039(94)02228-4

Source and publish data:

Tetrahedron Letters p. 225 - 228 (1995)

Update date:2022-08-04

Topics: Facile Synthesis 2-Substituted

Authors:

Strekowski, Lucjan

Gulevich, Yuri

Aken, Koen Van

Wilson, David W.

Fox, Keith R.

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Article abstract of DOI:10.1016/0040-4039(94)02228-4

N-substituted 2-(2-naphthyl)quinolin-4-amines 4b,c are superior to other DNA intercalators reported to date in the ability to selectively stabilize triple helix DNA in the presence of duplex DNA.A facile synthesis of the title diamines 1 required for the

Full text of DOI:10.1016/0040-4039(94)02228-4

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