992-78-9

Usage

Uses

Used in Pharmaceutical Industry:
Ubiquinol is used as a reduced coenzyme Q for improving nervous system cell functions. Its antioxidant properties and ability to trap lipid peroxyl radicals make it a promising candidate for the treatment of various neurological disorders and age-related cognitive decline.
Used in Antioxidant Applications:
Ubiquinol is used as an antioxidant for its ability to trap lipid peroxyl radicals and inhibit lipid peroxidation, helping to prevent ferroptosis. This makes it a valuable component in the development of therapies targeting oxidative stress-related diseases and conditions.
Used in Energy Production:
Ubiquinol plays a crucial role in the electron transport chain, acting as an electron shuttle between mitochondrial complexes. This function is essential for cellular respiration and energy production, making ubiquinol a key component in maintaining cellular health and function.

Upstream product

• 114832-98-3 1,4-Bis-benzyloxy-2-((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-tetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl)-5,6-dimethoxy-3-methyl-benzene 
• 303-98-0 ubidecarenone 
• 918799-20-9 1-((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl)-2,3,4-trimethoxy-5-((2-methoxyethoxy)methoxy)-6-methylbenzene 
• 70238-42-5 (2E)-4-[2,5-bis(benzyloxy)-3,4-dimethoxy-6-methylphenyl]-2-methylbut-2-en-1-ol 
• 303-97-9 ubiquinone-45 
• 2394-68-5 ubiquinone 8 
• 303-95-7 Ubichinon-7 
• 7200-27-3 5-demethoxyubiquinone-10 
• 50-81-7 ascorbic acid 
• 116854-25-2 1,4-dibenzyloxy-2,3-dimethoxy-5-methyl-6-(34'-hydroxy-3',7',11',15',19',23',27',31',35'-nonamethylhexatriaconta-2'E,6'E,10'E,14'E,18'E,22'E,26'E,30'E,35'-nonaenyl)benzene 
• 35189-96-9 3-methyl-2-butenylmagnesium chloride 
• 70854-64-7 solanesyl p-tolyl sulphone 
• 66958-69-8 1,4-bis(benzyloxy)-2-[(2E)-4-bromo-3-methylbut-2-enyl]-5,6-dimethoxy-3-methylbenzene 
• 13190-97-1 solanesol 

Downstream Products

• 28645-33-2 Hydronbichinon-bis-methylcarbamat 
• 55823-68-2 1,4-diacetoxy-2,3-dimethoxy-5-methyl-6-decaprenylbenzene 
• 122338-92-5 C₅₉H₉₄O₁₀P₂ 
• 303-98-0 ubidecarenone 

Relevant academic research and scientific papers

Method for synthesizing coenzyme Q10 from 5-demethoxy coenzyme Q10

The invention relates to a method for synthesizing a coenzyme Q10 from a 5-demethoxy coenzyme Q10. The method comprises the following steps of: taking the 5-demethoxy coenzyme Q10 as a raw material, and carrying out a 1,4-addition reaction, a methoxylation reaction and an oxidation reaction to finally prepare the coenzyme Q10. According to the method, the 5-demethoxy coenzyme Q10 is used as a rawmaterial, the process route is short, the yield is high, the product purity is high, the content detected by adopting HPLC (High Performance Liquid Chromatography) of a pharmacopoeia analysis method is 98% or more, and the problem of a byproduct 5-demethoxy coenzyme Q10 generated in a production fermentation process of the coenzyme Q10 is solved, thereby changing wastes into valuables.

FORMULATIONS OF LIPOPHILIC BIOACTIVE MOLECULES

This invention provides aqueous and non-aqueous clear formulations including at least one lipophilic bioactive molecules and an amphiphilic solubilizing agent. Exemplary aqueous formulations include a water-soluble reducing agent, which diminishes or prevents chemical degradation of the lipophilic bioactive molecule. The invention also provides methods of using the formulations of the invention. For example, the invention provides beverages including the formulations of the invention. The invention further provides methods of making the formulations and beverages.

COMPOSITION CONTAINING REDUCED COENZYME Q10, AND MANUFACTURING AND STABILISING METHODS THEREFOR

The present invention relates to a method of producing reduced coenzyme Q10, including reducing oxidized coenzyme Q10 using a reducing agent in terpenes that can highly dissolve oxidized coenzyme Q10 and reduced coenzyme Q10 in the co-existence of at least one kind of additive selected from the group consisting of alcohols, water, a surfactant and diacylglycerol. In addition, the present invention relates to a composition comprising terpenes, a reducing agent, reduced coenzyme Q10 and at least one kind selected from the group consisting of alcohols, water, a surfactant and diacylglycerol, and a method of stabilizing reduced coenzyme Q10 comprising preparing the composition.

Dietary chlorophyll metabolites catalyze the photoreduction of plasma ubiquinone

Ubiquinol is a plasma antioxidant. The mechanisms responsible for maintenance of plasma ubiquinol are poorly understood. Here, we show that metabolites of chlorophyll can be found in blood plasma of animals that are given a chlorophyll-rich diet. We also show that these metabolites catalyze the reduction of plasma ubiquinone to ubiquinol in the presence of ambient light, in vitro. We propose that dietary chlorophyll or its metabolites, together with light exposure, regulate plasma redox status through maintaining the ubiquinol pool. Blood vessels growing toward the light: can light protect blood plasma from oxidative damage?

Kinetic study of the α-tocopherol-regeneration reaction of ubiquinol-10 in methanol and acetonitrile solutions: Notable effect of the alkali and alkaline earth metal salts on the reaction rates

A kinetic study of regeneration reaction of α-tocopherol (α-TocH) by ubiquinol-10 has been performed in the presence of four kinds of alkali and alkaline earth metal salts (LiClO4, NaClO4, NaI, and Mg(ClO4)2) in methanol and acetonitrile solutions, using double-mixing stopped-flow spectrophotometry. The second-order rate constants (kr's) for the reaction of α-tocopheroxyl (α-Toc?) radical with ubiquinol-10 increased and decreased notably with increasing concentrations of metal salts in methanol and acetonitrile, respectively. The kr values increased in the order of no metal salt 4 ～ NaI 4 4)2 at the same concentration of metal salts in methanol. On the other hand, in acetonitrile, the kr values decreased in the order of no metal salt > NaClO4 ～ NaI > LiClO4 > Mg(ClO4)2 at the same concentration of metal salts. The metal salts having a smaller ionic radius of cation and a larger charge of cation gave a larger kr value in methanol, and a smaller k r value in acetonitrile. The effect of anion was almost negligible in both the solvents. Notable effects of metal cations on the UV-vis absorption spectrum of α-Toc? radical were observed in aprotic acetonitrile solution, suggesting complex formation between α-Toc? and metal cations. On the other hand, effects of metal cations were negligible in protic methanol, suggesting that the complex formation between α-Toc? and metal cations is hindered by the hydrogen bond between α-Toc? and methanol molecules. The difference between the reaction mechanisms in methanol and acetonitrile solutions was discussed on the basis of the results obtained. High concentrations of alkali and alkaline earth metal salts coexist with α-TocH and ubiquinol-10 in plasma, blood, and many tissues, suggesting the contribution of the metal salts to the above regeneration reaction in biological systems.

METHOD FOR PRODUCTION OF REDUCED COENZYME Q10 USING WATER-CONTAINING ORGANIC SOLVENT

The present invention aims to provide reduced coenzyme Q10, which is useful as food, food with nutrient function claims, food for specified health use, nutritional supplement, nutritional product, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, and a production method of reduced coenzyme Q10. The present invention provides a production method of reduced coenzyme Q10, which includes reducing oxidized coenzyme Q10 with ascorbic acid or its analogue(s) as a reducing agent in a water-containing organic solvent at not more than pH 5. Using the method, the reaction time can be drastically shortened even without adding a basic substance and the like, and unpreferable side reactions can be minimized. Therefore, reduced coenzyme Q10 with high quality can be produced.

COMPOSITIONS CONTAINING COENZYME Q-10 AND DIHYDROLIPOIC ACID

The invention describes compositions, including soft gelatin capsules, that include dihydrolipoic acid and the reduced form of coenzyme Qn wherein the dihydrolipoic acid acts as a reducing agent for the coenzyme Qn and also, optionally, as a solvent.

Composition containing reduced coenzyme Q10 and production method thereof

The present invention provides a particulate composition wherein an oil component containing reduced coenzyme Q10 is polydispersed forming a domain in a matrix containing a water-soluble excipient, which simultaneously shows high oxidative stability and high oral absorbability, a production method thereof, and a stabilizing method thereof. It also provides a food, food with nutrient function claims, food for specified health uses, dietary supplement, nutritional product, animal drug, drink, feed, pet food, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, which contain the composition.

SKIN AGENT FOR EXTERNAL USE AND COSMETIC AGENT INCLUDING UBIQUINONE DERIVATIVE OR SALT THEREOF AND METHOD USING THE SAME

A skin agent for external use and a cosmetic agent are provided, by transdermal administration of which expected actions and effects of ubiquinone derivatives, salts thereof, ubiquinones and ubiquinols are effectively obtained. The skin agent for external use includes a ubiquinone derivative or a salt thereof as an active ingredient. The ubiquinone derivative is represented by the formula (1): wherein R1 and R2 are each a hydrogen atom or a phosphoric group, at least one of R1 and R2 is a phosphoric group, and n is an integer in the range of 1 to 9.

COMPOSITION FOR LIFE EXTENSION AND METHOD OF EXTENDING THE LIFE

The present invention relates to a composition for life extension, comprising reduced coenzyme Q10 as an active ingredient, as well as relates to a method of extending a life span using the composition comprising reduced coenzyme Q10 as an active ingredient. In the present invention, it has been found that long-term ingestion of feed that contains reduced coenzyme Q10 enables the life span of senescence-accelerated model mice to be extended. No sign indicating toxicity is observed in the senescence-accelerated model mice that have been fed with reduced coenzyme Q10 over a long period. Based on these findings, it was found that the composition containing reduce coenzyme Q10 as an active ingredient has potential to be a composition for life extension with high safety, capable of being taken for a long period. The present invention provides a composition, which can extend the life span of humans or animals, enables them to spend active and healthy senectitudes and shows high safety during the ingestion over a long period.