Formal synthesis of (+)-α-conhydrine and stereoselective synthesis of pyrrolidine analogue via the diastereoselective chelation-controlled hydride reduction and wittig reaction

Article abstract of DOI:10.1080/00397911.2014.899605

Asymmetric syntheses of (+)-α-conhydrine and its pyrrolidine analogue were achieved from readily available L-serine. The key step involved highly diastereoselective chelation-controlled hydride reduction of the amino ketone to give the anti-amino alcohol