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987-78-0 Usage


Citicoline whose chemical name choline cytosine nucleoside-5'-diphosphate monosodium salt, is a precursor for lecithin biosynthesis, and when brain function declines, the content of lecithin in brain tissue is significantly reduced.




Cytidine 5'-Diphosphocholine is used as antidepressant, 5HT uptake inhibitor.

Manufacturing Process

A 250 ml conical flask containing 30 ml of a reaction liquor (pH 7.0) having a composition of 7.38 mg/ml of disodium salt of CMP (cytidine-5'- monophosphate), 24 mg/ml of choline, 10 mg/ml of glucose, 100 mg/ml of acetone-dried cells of Brevibacterium ammoniagenes ATCC 6872, 11.6 mg/ml of monopotassium phosphate, 20 mg/ml of dipotassium phosphate and 2.96 mg/ml of magnesium sulfate, (MgSO4·7H2O), was subjected to culturing at 30°C for 4 hours. Cytidine diphosphate choline was formed and accumulated at a concentration of 3.8 mg/ml in the culture liquor. The pH of 1.2 liters of filtrate containing 3.8 mg/ml of cytidine diphosphate choline, obtained by removing solid matters from the culturing liquor, was adjusted to a pH of 8.5 with a 0.5 N KOH solution. The filtrate was passed through a column of strongly basic anion exchange resin, Dowex 1 x 2 (formic acid type). After washing the resin with water, a formic acid solution was passed through the column with gradual increase in the concentration of formic acid (until 0.04 N max.). A fraction of cytidine diphosphate choline was collected by elution according to the so-called gradient elution method and absorbed onto carbon powders. Then, elution was effected with acetone, and the eluate was concentrated and dried. 1.3 g of cytidine diphosphate choline powders were obtained.

Therapeutic Function

Cerebral circulation stimulant

Check Digit Verification of cas no

The CAS Registry Mumber 987-78-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,8 and 7 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 987-78:
120 % 10 = 0
So 987-78-0 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name CDP-choline

1.2 Other means of identification

Product number -
Other names nicholin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:987-78-0 SDS

987-78-0Relevant articles and documents

Citicoline and synthesizing method of citicoline not using phosphocholine chloride calcium


Paragraph 0017, (2016/11/17)

The invention discloses citicoline and a synthesizing method of citicoline not using phosphocholine chloride calcium. The synthesizing method does not use phosphocholine chloride calcium, and comprises the following three steps of using dichloride phosphoryl morpholine with low cost and easy obtaining as a raw material, and reacting with ethylene glycol, so as to obtain glycol ester phosphoryl morpholine; continuously and directly is in condensation with cytidine monophosphate, so as to obtain glycol ester phosphoryl cytidine monophosphate; finally, opening a loop of gylcol ester of the glycol ester phosphoryl monophosphate by tributylamine, so as to obtain the citicoline, wherein the total yield is 78 percent. The synthesizing method has the advantages that the cost of raw material is low, and the obtaining is easy, so that the use of DCC (dicyclohexylcarbodiimide) and phosphocholine chloride calcium with high cost and toxicity is avoided; when the reaction scale is expanded to 500g, the yield is not obviously decreased; a new synthesizing path is provided for the synthesis of the citicoline, and the potential application prospect is realized.

Citicoline and synthetic method thereof


Paragraph 0014; 0016; 0019, (2016/10/24)

The invention discloses citicoline and a synthetic method thereof.The synthetic method includes subjecting cheap and easily available cytidine, serving as a raw material, and dichlorophosphoryl morpholine to condensation at a 5' position highly selectively so as to obtain 5'-phosphorylmorpholinylcytidine; subjecting the 5'-phosphorylmorpholinylcytidine and phosphocholine chloride calcium to condensation in solvents so as to obtain the citicoline.Total yield is up to 58% only by the two steps.The synthetic method is cheap in and easily available to raw materials, expensive cytidine monophosphate is unused, operation steps are simplified, and reaction scale can be expanded to synthesize 500 g of citicoline.The synthetic method has a potential application prospect by providing a novel citicoline synthetic route.



Page/Page column 15-18, (2008/12/06)

A method of purifying cytidine diphosphate choline, which comprises contacting a cytidine diphosphate choline solution containing a nucleic acid analogue and having a pH of not less than 0.5 and not more than 5.0 with an H-type strongly acidic cation exchange resin, and eluting cytidine diphosphate choline adsorbed onto the resin with water or an aqueous solution having an ion concentration of not more than 0.1 mol/L to separate and purify the cytidine diphosphate choline.

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