Stereocontrolled Aldol Additions to α-Methylene-β-Alkoxy Aldehydes: Application to the Synthesis of a C13-C25 Segment of Bafilomycin A1.

Article abstract of DOI:10.1016/0040-4039(94)02205-P

A boron-mediated, syn-aldol coupling between ethyl ketone 8 and aldehyde 9, followed by directed hydrogenation at C₁₆ and acetonide hydrolysis, gives the C₁₃-C₂₅ segment 6 of bafilomycin A₁.