
Tetrahedron p. 1985 - 1994 (1995)
Update date:2022-08-04
Topics:
Marder, Raphaele
Dubois, Joelle
Guenard, Daniel
Gueritte-Voegelein, Francoise
Potier, Pierre
Zinc-promoted reduction of 13-oxobaccatin III derivatives leads to 11,12-dihydro analogs. The reduced products are unstable and a skeleton rearrangement occurs leading to the cleavage of the C-10, C-11 bond. The 11,12-dihydrobaccatin III derivatives do not retain antitubulin activity.
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