Task-specific ionic liquid-mediated facile synthesis of 1,3,5 triaryltriazines by cyclotrimerization of imines and their biological evaluation

Article abstract of DOI:10.1246/cl.130839

A highly efficient method for the synthesis of fluorinated 1,3,5-triaryltriazine derivatives is developed by the condensation reaction of aromatic amines and formaldehyde followed by spontaneous cyclotrimerization using task-specific 1,1,3,3-tetramethylguanidine trifluoroacetate [TMG][Tfa] ionic liquid as a environmentally benign solvent in excellent yields at room temperature. The synthesized compounds were subjected for in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv strain using the LoewensteinJensen medium.