(13)C- and (15)N-NMR.-Spectroscopic Studies on (6RS)-5,10-Methylene-5,6,7,8-tetrahydro-L-folic Acid; Unequivocal Proof of their Structure

Article abstract of DOI:10.1002/hlca.19810640821

The existence of a 5,10-methylene bridge in the title compound has been established with the help of (15)N-NMR. and (13)C-NMR. spectroscopy.The simultaneous coupling of (13)C(11) with (15)N(5) and (15)N(1O) proves that C(11) must be bound as a methylene bridge to both N-atoms.Some other aspects of the NMR. spectra of the compound are discussed.Synthesis of the title product with the label (15)N is described.