Synthesis of Optically Active α-Methylene γ-Butyrolactones and (+)-Mintlactone

Article abstract of DOI:10.1016/0040-4020(95)00236-2

The combination of baker's yeast reductions of β-keto carbonyls, vinyl triflate formation and a palladium-catalysed, intramolecular, carbonylative coupling affords optically active α-methylene γ-butyrolactones.The synthesis of the unnatural (+)-mintlacton